[题名] 微加工全氟聚合物（Teflons）的最新进展及其在微流体中的相关新应用

[作者] Yisu Wang, Siyu Chen, Han Sun , Wanbo Li , Chong Hu , Kangning Ren

[摘要] 在过去的二十年中，微流控已成为许多领域的使能技术，包括细胞生物学、生物物理学、生物化学、光子流体学等。同时，由于其带来的问题和独特功能，研究人员越来越关注器件材料。聚二甲基硅氧烷（PDMS）是目前微流控研究中流行的材料，但也存在一些缺点，例如吸收小分子和与有机溶剂兼容性差。因此，全氟聚合物（Teflon）进入了研究人员的视野，它保留了PDMS的大部分优点，同时具有出色的惰性和抗污染性能。在最初的阶段，液态Teflon直接涂在PDMS上，随后成功地制造出了全Teflon微流控芯片，并在长期细胞培养、涉及有机溶剂的合成等方面表现出色。自那时以来，金属、生物分子和其他塑料等材料已集成到Teflon芯片中，并将其应用扩展到了电化学传感和免疫测定等领域。此外，全氟聚合物因其不粘附性而被广泛用于辅助模具释放。为了说明这一进展，本综述着重介绍了Teflon在微流控领域中的最新发展，并就这一趋势进行了深入的讨论。

[关键词] 全氟化聚合物、铁氟龙、微加工、微流体

[Title] Recent progresses in microfabricating perfluorinated polymers (Teflons) and the associated new applications in microfluidics

[Author] Yisu Wang, Siyu Chen, Han Sun , Wanbo Li , Chong Hu , Kangning Ren

[Abstract] During the past two decades, microfluidics has become an enabling technology in many fields,  including cell-biology, biophysics, biochemistry, optofluidics, etc. In the meantime, researchers are paying  more attention to device materials because of the problems and unique functions they brought. As the most  popular material in current microfluidic research, polydimethylsiloxane (PDMS) also has some drawbacks,  such as absorption of small molecules and poor organic solvent compatibility. Thus, perfluorinated polymers  (Teflons), which retain most advantages of PDMS but also has excellent inertness and anti-fouling properties,  came into researchers’ perspective. After the initial period when liquid Teflon were directly coated on  PDMS, whole-Teflon microfluidic chips were successfully fabricated and performed excellently in long-term  cell culture, organic solvent-involved synthesis, etc. Since then, materials such as metals, biomolecules and  other plastics have been integrated into Teflon chips and expanded their use to electrochemical sensing and  immunoassay. Furthermore, perfluoropolymers have also been broadly used to assist mold release due to  their nonstick property. Aiming to illustrate this progress, current review focuses on the recent development  of Teflon microfabrication and applications in microfluidics, and provides critical discussion on this trend.

[Keywords] Perfluorinated polymer; Teflon; microfabrication; microfluidics